Unexpected healing of cutaneous ulcers in a short child

A boy aged 10 years was referred to the Paediatric Department of Milan University Hospital, Milan, Italy, with a long history of pain in the lower limbs, alleviated only by exposure to cold. His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapaci...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-07, Vol.358 (9277), p.211-212
Main Authors: Cimaz, Rolando, Rusconi, Roberto, Fossali, Emilio, Careddu, Paolo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood pressure
Child
Crises
Erythromelalgia - drug therapy
Erythromelalgia - etiology
Growth Hormone - therapeutic use
Hormones
Human Growth Hormone - deficiency
Humans
Leg Ulcer - drug therapy
Leg Ulcer - etiology
Legs
Male
Medical research
Medical sciences
Pain
Pediatrics
Pharmacology. Drug treatments
Skin, nail, hair, dermoskeleton
Ulcers
Wound Healing - drug effects
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Summary:A boy aged 10 years was referred to the Paediatric Department of Milan University Hospital, Milan, Italy, with a long history of pain in the lower limbs, alleviated only by exposure to cold. His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapacitated. After the diagnosis of erythermalgia was made, numerous treatments were tried, but none were successful. After finding growth hormone (GH) deficiency, we started treatment with recombinant GH. He had immediate relief of pain and complete healing of ulcers. We postulate that the healing of the ulcers can be attributed to the GH-promoting effect on dermal connective tissue.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(01)05413-7