HIV nucleoside analogues: new adverse effects on mitochondria?

A recent report by Blanche and colleagues suggests that prenatal exposure to nucleoside-analogue reverse-transcriptase inhibitors may lead to toxic effects in the mitochondria of infants, but Morris and Carr argue that further studies are needed to confirm or refute this.

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Bibliographic Details
Published in:The Lancet (British edition) 1999-09, Vol.354 (9184), p.1046-1047
Main Authors: Mor ris, Andrew AM, Carr, Andrew
Format: Article
Language:English
Subjects:
Babies
Drug therapy
Female
HIV
HIV Infections - prevention & control
HIV Infections - transmission
Human immunodeficiency virus
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical - prevention & control
Medical research
Mitochondria - drug effects
Nucleosides - adverse effects
Pregnancy
Reverse Transcriptase Inhibitors - adverse effects
Toxicity
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Description
Summary:A recent report by Blanche and colleagues suggests that prenatal exposure to nucleoside-analogue reverse-transcriptase inhibitors may lead to toxic effects in the mitochondria of infants, but Morris and Carr argue that further studies are needed to confirm or refute this.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(99)00301-3