Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of syste...

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Bibliographic Details
Published in:The Lancet (British edition) 1992-10, Vol.340 (8823), p.819-820
Main Authors: Kinsella, J.P, Neish, S.R, Shaffer, E, Abman, S.H
Format: Article
Language:English
Subjects:
Babies
Blood pressure
Gases
Hypertension
Infants
Medical disorders
Medical research
Nitric oxide
Oxygen
Oxygenation
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Summary:We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(92)92687-B