Acarbose-induced acute severe hepatotoxicity

The temporal relation between the initiation of acarbose and the onset of the liver injury, in addition to the effects of the discontinuation and resumption of the drug, are highly suggestive of acarbose-induced acute hepatotoxicity.

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Bibliographic Details
Published in:The Lancet (British edition) 1997-03, Vol.349 (9053), p.698-699
Main Authors: Carrascosa, Miguel, Pascual, Francisco, Aresti, Santiago
Format: Article
Language:English
Subjects:
Acarbose
Adult
Biological and medical sciences
Chemical and Drug Induced Liver Injury - etiology
Diabetes Mellitus, Type 2 - drug therapy
Drug therapy
Drug toxicity and drugs side effects treatment
Drugs
Enzyme Inhibitors - adverse effects
Female
Hepatotoxicity
Humans
Hypoglycemic Agents - adverse effects
Liver
Medical sciences
Pharmacology. Drug treatments
Toxicity: digestive system
Toxicology
Trisaccharides - adverse effects
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Description
Summary:The temporal relation between the initiation of acarbose and the onset of the liver injury, in addition to the effects of the discontinuation and resumption of the drug, are highly suggestive of acarbose-induced acute hepatotoxicity.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)60134-1