Hepatitis B virus clearance by transplantation of bone marrow from hepatitis B immunised donor

Brugger et al suggest an exclusively HBsAg-specific clearance of hepatitis B virus infection. However, they cannot completely exclude the possibility that the donor mounted a primary but only transient immune response against HBcAG earlier.

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Bibliographic Details
Published in:The Lancet (British edition) 1997-04, Vol.349 (9057), p.996-997
Main Authors: Brugger, Stefan A, Oesterreicher, Christian, Holfmann, Hanns, Kalhs, Peter, Greinix, Hildegard T, Müller, Christian
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bone marrow
Bone Marrow Transplantation - immunology
Bone marrow, stem cells transplantation. Graft versus host reaction
Hepatitis
Hepatitis B
Hepatitis B Antibodies - immunology
Hepatitis B Surface Antigens - immunology
Hepatitis B Vaccines - administration & dosage
HIV
Human immunodeficiency virus
Humans
Immune response
Immunization
Male
Medical sciences
Tissue Donors
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplants & implants
Vaccination
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Description
Summary:Brugger et al suggest an exclusively HBsAg-specific clearance of hepatitis B virus infection. However, they cannot completely exclude the possibility that the donor mounted a primary but only transient immune response against HBcAG earlier.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)62893-0