Spontaneous lymphocyte proliferation in HTLV-II infection

We measured lymphocyte proliferation in the absence of antigenic stimulation in 45 HTLV-II infected, 9 HTLV-I infected, and 19 HTLV-I seronegative intravenous drug users (IVDU). Lymphocyte proliferation was higher in IVDUs infected with HTLV-II than in seronegative IVDUs but lower than among those i...

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Bibliographic Details
Published in:The Lancet (British edition) 1991-02, Vol.337 (8737), p.327-328
Main Authors: Wiktor, S.Z, Blattner, W.A, Jacobson, S, Reuben, J.S, MacFarlin, D.E, Weiss, S.H, Shaw, G.M, Short, V.J
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Biological and medical sciences
Diagnosis, Differential
Drug abuse
Female
HTLV-I Infections - blood
HTLV-I Infections - diagnosis
HTLV-II Infections - blood
HTLV-II Infections - diagnosis
Human viral diseases
Humans
Infections
Infectious diseases
Lymphocyte Activation - physiology
Lymphocytes
Male
Medical sciences
Polymerase Chain Reaction
Substance Abuse, Intravenous - blood
Substance Abuse, Intravenous - complications
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:We measured lymphocyte proliferation in the absence of antigenic stimulation in 45 HTLV-II infected, 9 HTLV-I infected, and 19 HTLV-I seronegative intravenous drug users (IVDU). Lymphocyte proliferation was higher in IVDUs infected with HTLV-II than in seronegative IVDUs but lower than among those infected with HTLV-I. Higher rates of proliferation were also associated with needle sharing, CD4+ and IL2R+ lymphocyte counts, and HTLV-I antibody titres.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(91)90947-N