Insulin vasodilatation and the “arginine paradox”

It appears that during local hyperinsulinemia, L-arginine administration produces stereospecific vasodilation. Ueda et al hypothesize that abnormal L-arginine transport may account for impaired insulin-mediated vasodilatation in states of insulin resistance.

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Bibliographic Details
Published in:The Lancet (British edition) 1998-03, Vol.351 (9107), p.959-960
Main Authors: Ueda, Shinichiro, Petrie, John R, Cleland, Stephen J, Elliott, Henry L, Connell, John MC
Format: Article
Language:English
Subjects:
Adult
Arginine - physiology
Biological and medical sciences
Cross-Over Studies
Digestive system
Double-Blind Method
Endothelium, Vascular - physiology
Humans
Insulin
Male
Medical research
Medical sciences
Nitric Oxide - physiology
Pharmacology. Drug treatments
Vasodilation - physiology
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Description
Summary:It appears that during local hyperinsulinemia, L-arginine administration produces stereospecific vasodilation. Ueda et al hypothesize that abnormal L-arginine transport may account for impaired insulin-mediated vasodilatation in states of insulin resistance.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)60615-0