Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study

Summary Background Critically ill infants and children often develop hyperglycaemia, which is associated with adverse outcome; however, whether lowering blood glucose concentrations to age-adjusted normal fasting values improves outcome is unknown. We investigated the effect of targeting age-adjuste...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 2009-02, Vol.373 (9663), p.547-556
Main Authors: Vlasselaers, Dirk, MD, Milants, Ilse, RN, Desmet, Lars, MD, Wouters, Pieter J, MSc, Vanhorebeek, Ilse, PhD, van den Heuvel, Ingeborg, MD, Mesotten, Dieter, MD, Casaer, Michael P, MD, Meyfroidt, Geert, MD, Ingels, Catherine, MD, Muller, Jan, MD, Van Cromphaut, Sophie, MD, Schetz, Miet, MD, Van den Berghe, Greet, Prof
Format: Article
Language:English
Subjects:
Adolescent
Adults
Belgium
Blood
Blood Glucose - drug effects
Child
Child, Preschool
Clinical medicine
College admissions
Critical Care - methods
Diabetes
Female
Glucose
Heart surgery
Hospital Mortality
Hospitals
Humans
Hypoglycemia - chemically induced
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Infant
Infant, Newborn
Infants
Insulin
Insulin - administration & dosage
Insulin - adverse effects
Insulin - therapeutic use
Intensive care
Intensive Care Units, Pediatric
Internal Medicine
Length of Stay
Male
Medical disorders
Mortality
Prospective Studies
Risk factors
Survival
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background Critically ill infants and children often develop hyperglycaemia, which is associated with adverse outcome; however, whether lowering blood glucose concentrations to age-adjusted normal fasting values improves outcome is unknown. We investigated the effect of targeting age-adjusted normoglycaemia with insulin infusion in critically ill infants and children on outcome. Methods In a prospective, randomised controlled study, we enrolled 700 critically ill patients, 317 infants (aged
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(09)60044-1