Effect on stroke of different progestagens in low oestrogen dose oral contraceptives

The multicentre WHO collaborative case-control study had limited power to differentiate stroke risks by progestagen component in low dose combined oral contraceptives. Given this caveat, odds ratios for ischaemic, haemorrhagic, and all strokes combined associated with use of oral contraceptives cont...

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Bibliographic Details
Published in:The Lancet (British edition) 1999-07, Vol.354 (9175), p.301-302
Main Authors: Poulter, NR, Chang, CL, Farley, TMM, Marmot, MG, Meirik, O
Format: Article
Language:English
Subjects:
Biological and medical sciences
Birth control
Case studies
Contraceptives
Drug toxicity and drugs side effects treatment
Health risks
Medical research
Medical sciences
Pharmacology. Drug treatments
Stroke
Toxicity: nervous system and muscle
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Summary:The multicentre WHO collaborative case-control study had limited power to differentiate stroke risks by progestagen component in low dose combined oral contraceptives. Given this caveat, odds ratios for ischaemic, haemorrhagic, and all strokes combined associated with use of oral contraceptives containing desogestrel or gestodene (“third generation”) were found to be similar to those containing levonorgestrel in this study.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(99)01013-2