Cardiovascular effects of tight versus usual blood-pressure control/Authors' reply

[...] although Verdecchia and colleagues recognise the effect of lack of double-blinding on clinical decisions related to secondary outcome events, they do not acknowledge that this bias may have indirectly contributed to the higher incidence of LVH in the usual-control group. [...] the potential dr...

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Bibliographic Details
Published in:The Lancet (British edition) 2009-11, Vol.374 (9703), p.1741
Main Authors: Rai, Saurabh, Nandan, Nidhi, Tiwari-Pandey, Rashmi, Pandey, Nihar R, Green, Jonas B, Richards, Adam K, Verdecchia, Paolo, Angeli, Fabio, Staessen, Jan A, Reboldi, Gianpaolo
Format: Article
Language:English
Subjects:
Colleges & universities
Health services
Hospitals
Hypertension
Internal medicine
Online Access:Get full text
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Summary:[...] although Verdecchia and colleagues recognise the effect of lack of double-blinding on clinical decisions related to secondary outcome events, they do not acknowledge that this bias may have indirectly contributed to the higher incidence of LVH in the usual-control group. [...] the potential drug combinations were so many to preclude any meaningful comparison. [...] since the readers of electrocardiographic tracings were unaware of the randomisation code, the potential bias introduced by the open design did not extend to the assessment of LVH, the primary endpoint of the study.
ISSN:0140-6736
1474-547X