Pesticide exposure and risk of mild cognitive dysfunction

Little is known about the adverse effects of substances, such as pesticides and metals, on the development of mild cognitive dysfunction (MCD). Cross-sectional and prospective data from the Maastricht Aging Study were used to find out the potential neurotoxicity of particular substances. Exposure to...

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Bibliographic Details
Published in:The Lancet (British edition) 2000-09, Vol.356 (9233), p.912-913
Main Authors: Bosma, H, van Boxtel, MPJ, Ponds, RWHM, Houx, PJ, Jolles, J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Agriculture
Biological and medical sciences
Cognition & reasoning
Cognition Disorders - chemically induced
Cohort Studies
Cross-Sectional Studies
Environmental Exposure
Exposure
Farmers
Female
Follow-Up Studies
Gardens & gardening
Health risk assessment
Humans
Male
Medical research
Medical sciences
Metals - adverse effects
Middle Aged
Netherlands
Neurological disorders
Neurotoxicity
Neurotoxins - adverse effects
Organic solvents
Pesticides
Pesticides - adverse effects
Pesticides, fertilizers and other agrochemicals toxicology
Prospective Studies
Risk Factors
Solvents
Solvents - adverse effects
Toxicology
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Summary:Little is known about the adverse effects of substances, such as pesticides and metals, on the development of mild cognitive dysfunction (MCD). Cross-sectional and prospective data from the Maastricht Aging Study were used to find out the potential neurotoxicity of particular substances. Exposure to pesticides, for example by arable farmers and gardeners, was associated with increased risks of MCD. Exposure to metals and organic solvents was not associated with MCD. Our findings might reflect subtle changes in brain function among people exposed to pesticides.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)02685-4