Acute and chronic exposure of rat intestinal mucosa to dextran promotes SGLT1-mediated glucose transport

Background The intestinal handling of dextran, an α‐1,6‐linked glucose polymer, is poor compared with starch, and some ingested dextran might therefore reach the lower small intestine. As luminal sugar up‐regulates SGLT1 (sodium‐dependent glucose transporter) locally, we report the effects of a dext...

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Bibliographic Details
Published in:European journal of clinical investigation 1998-08, Vol.28 (8), p.651-658
Main Authors: Debnam, E S, Denholm, E E, Grimble, G K
Format: Article
Language:English
Subjects:
Brush border membrane
dietary carbohydrate
intestinal epithelium
luminal sugar
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Summary:Background The intestinal handling of dextran, an α‐1,6‐linked glucose polymer, is poor compared with starch, and some ingested dextran might therefore reach the lower small intestine. As luminal sugar up‐regulates SGLT1 (sodium‐dependent glucose transporter) locally, we report the effects of a dextran‐enriched diet on jejunal and ileal brush border membrane (BBM) glucose uptake. Methods Rats were maintained on a diet containing 65% maltodextrin or 32.5% maltodextrin + 32.5% dextran (10 kD or 40 kD) for 8–10 days, and the kinetics of phlorizin‐sensitive [3H]‐glucose uptake by purified BBM vesicles was determined. Results Ingestion of 40‐kD but not 10‐kD dextran increased Vmax for jejunal and ileal glucose uptake (+64.3% and +61.8% respectively, both P 
ISSN:0014-2972
1365-2362
DOI:10.1046/j.1365-2362.1998.00352.x