The Relationship Between Copper, Iron, and Selenium Levels and Alzheimer Disease

This study aimed to evaluate the concentrations of copper, iron, and selenium in elderly people with Alzheimer disease (AD), comparing the same parameters in a paired group of healthy people, in order to verify if the amount of these metals may influence the cognitive impairment progression. Patient...

Full description

Saved in:
Bibliographic Details
Published in:Biological trace element research 2018-02, Vol.181 (2), p.185-191
Main Authors: Vaz, Felipe Nathanael Coelho, Fermino, Bárbara Luisa, Haskel, Maria Vaitsa Loch, Wouk, Jéssica, de Freitas, Guilherme Barroso Langoni, Fabbri, Roberta, Montagna, Erik, Rocha, João Batista Teixeira, Bonini, Juliana Sartori
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer's disease
Biochemistry
Biomedical and Life Sciences
Biotechnology
Blood levels
Cognitive ability
Copper
Copper - blood
Dementia disorders
Disease control
Erythrocytes
Female
Geriatrics
Heavy metals
Humans
Impairment
Inductively coupled plasma mass spectrometry
Iron
Iron - blood
Life Sciences
Male
Mass Spectrometry
Mass spectroscopy
Metal concentrations
Neurodegenerative diseases
Nutrition
Older people
Oncology
Patients
Selenium
Selenium - blood
Statistical analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to evaluate the concentrations of copper, iron, and selenium in elderly people with Alzheimer disease (AD), comparing the same parameters in a paired group of healthy people, in order to verify if the amount of these metals may influence the cognitive impairment progression. Patients’ cognitive impairment was evaluated by Clinical Dementia Rating (CDR). The elementary quantification of erythrocytes was performed by inductively coupled plasma mass spectrometry technique. The statistical analyses were carried out by SPSS software 20.0 version, employing Shapiro-Wilk, Wilcoxon, Kruskall-Wallis, and Spearman correlation tests, considering significant results of p  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-017-1042-y