Crystal structures of 1-aryl-4-(biarylmethylene)piperazine and piperidine, structurally related to adoprazine

• Published in: Journal of structural chemistry 2017-12, Vol.58 (8), p.1697-1702
• Main Authors: Ullah, N., Altaf, M., Mansha, M.
• Format: Article
• Language: English
• Subjects: Aromatic compounds; Atomic; Atomic/Molecular Structure and Spectra; Chemical bonds; Chemistry; Chemistry and Materials Science; Crystal structure; Dimers; Forming; Hydrogen bonds; Inorganic Chemistry; Molecular; Optical and Plasma Physics; Physical Chemistry; Piperidine; Solid State Physics
• ISSN: 0022-4766; 1573-8779
• DOI: 10.1134/S0022476617080339

8-(1-([1,1′-Biphenyl]-4-ylmethyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1 H )-one ( 1 ) and 8-(4-([1,1′- biphenyl]-4-ylmethyl)piperazin-1-yl)quinolin-2(1 H )-one ( 2 ) are prepared in the crystalline state and studied by X-ray diffraction. The crystal packing drawing of compound ( 1 ) indicates that individual molecules are linked by pairs of N–H∙∙∙O hydrogen bonds forming A–A and B–B inversion dimers, with R 2 2 (8) ring motifs. These dimers are stabilized by N–H∙∙∙O hydrogen bonds and linked via C–H∙∙∙O short contact interactions forming a two-dimensional network. In the case of compound ( 2 ), there are two independent molecules A and B linked by pairs of N–H∙∙∙O hydrogen bonds forming A–A and B–B inversion dimers, with R 2 2 (8) ring motifs. These dimers are stabilized by N–H∙∙∙O hydrogen bonds and linked via C–H∙∙∙O short contact interactions forming a two-dimensional network.