Preparation of Magnetic Fluorescent Dual-drug Nanocomposites for Codelivery of Kaempferol and Paclitaxel

Magnetic fluorescent dual-drug nanocomposites（MFDDs） were developed with the aim of simultaneouly delivering two different anticancer drugs, kaempferol（KAE） and paclitaxel（PTX）. Firstly, Fe3O4/bovine serum albumin（Fe3O4/BSA） composite microspheres with physically entrapped KAE were prepared, then mi...

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Bibliographic Details
Published in:Journal of Wuhan University of Technology. Materials science edition 2018-02, Vol.33 (1), p.256-262
Main Authors: 张小娟, PAN Qingqing, 郝凌云, LIN Qing, TIAN Xiangping, ZHANG Zhiying, WANG Shanshan, WANG Hehe
Format: Article
Language:English
Subjects:
Cancer
Chemical bonds
Chemistry and Materials Science
Chemotherapy
Drug delivery systems
Electron microscopy
Iron oxides
Magnetic measurement
Magnetic saturation
Materials Science
Microspheres
Nanocomposites
Quantum dots
Serum albumin
Toxicity
X-ray fluorescence
荧光灯
磁性
Fourier
电子显微镜
合作管理
Hela
光谱学
红外线
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Summary:Magnetic fluorescent dual-drug nanocomposites（MFDDs） were developed with the aim of simultaneouly delivering two different anticancer drugs, kaempferol（KAE） and paclitaxel（PTX）. Firstly, Fe3O4/bovine serum albumin（Fe3O4/BSA） composite microspheres with physically entrapped KAE were prepared, then microspheres were modified with PTX/graphene quantum dots（PTX/GQDs） through chemically bonding, and the MFDDs were obtained. The properties of nancomposites were characterized by X-ray diffractometry, Fourier-transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometry and X-ray fluorescence spectrometry. It was found that the superparamagnetic nanocomposites had ultrafine size（below 110 nm）, high saturation magnetization of 24.36 emu/g, and significant fluorescence. Furthermore, the cumulative in vitro release of the MFDDs exhibited controlled drug release. Cell viability experiments confirmed that the co-administration of KAE with PTX had a superior cytotoxicity to the Hela cells compared with single drug-loaded forms. Therefore, dual anticancer drug-loaded MFDDs have the potential to be used for cancer combined chemotherapy.
ISSN:1000-2413
1993-0437
DOI:10.1007/s11595-018-1814-z