Preparation of Magnetic Fluorescent Dual-drug Nanocomposites for Codelivery of Kaempferol and Paclitaxel

• Published in: Journal of Wuhan University of Technology. Materials science edition 2018-02, Vol.33 (1), p.256-262
• Main Authors: 张小娟, PAN Qingqing, 郝凌云, LIN Qing, TIAN Xiangping, ZHANG Zhiying, WANG Shanshan, WANG Hehe
• Format: Article
• Language: English
• Subjects: Cancer; Chemical bonds; Chemistry and Materials Science; Chemotherapy; Drug delivery systems; Electron microscopy; Iron oxides; Magnetic measurement; Magnetic saturation; Materials Science; Microspheres; Nanocomposites; Quantum dots; Serum albumin; Toxicity; X-ray fluorescence; 荧光灯; 磁性; Fourier; 电子显微镜; 合作管理; Hela; 光谱学; 红外线
• ISSN: 1000-2413; 1993-0437
• DOI: 10.1007/s11595-018-1814-z

Magnetic fluorescent dual-drug nanocomposites（MFDDs） were developed with the aim of simultaneouly delivering two different anticancer drugs, kaempferol（KAE） and paclitaxel（PTX）. Firstly, Fe3O4/bovine serum albumin（Fe3O4/BSA） composite microspheres with physically entrapped KAE were prepared, then microspheres were modified with PTX/graphene quantum dots（PTX/GQDs） through chemically bonding, and the MFDDs were obtained. The properties of nancomposites were characterized by X-ray diffractometry, Fourier-transform infrared spectroscopy, transmission electron microscopy, vibrating sample magnetometry and X-ray fluorescence spectrometry. It was found that the superparamagnetic nanocomposites had ultrafine size（below 110 nm）, high saturation magnetization of 24.36 emu/g, and significant fluorescence. Furthermore, the cumulative in vitro release of the MFDDs exhibited controlled drug release. Cell viability experiments confirmed that the co-administration of KAE with PTX had a superior cytotoxicity to the Hela cells compared with single drug-loaded forms. Therefore, dual anticancer drug-loaded MFDDs have the potential to be used for cancer combined chemotherapy.