Pathophysiology of obstructive sleep apnea-hypopnea syndrome (OSAHS)

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a disease characterized by recurrent upper airway obstruction (UAO), with decreased airflow, intermittent hypoxemia, and awakening during sleep. Two essential factors are related to the pathophysiology of OSAHS: anatomical alterations and reductio...

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Bibliographic Details
Published in:Revista de la Facultad de Medicina, Universidad Nacional de Colombia Universidad Nacional de Colombia, 2017-01, Vol.65 (1Supl), p.25
Main Authors: Venegas-Mariño, Marco, Juan Camilo Garcia
Format: Article
Language:Spanish
Subjects:
Airway management
Pathology
Sleep apnea
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Summary:Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a disease characterized by recurrent upper airway obstruction (UAO), with decreased airflow, intermittent hypoxemia, and awakening during sleep. Two essential factors are related to the pathophysiology of OSAHS: anatomical alterations and reduction or absence of neural control. While studying OSAHS, the site or sites of obstruction of the UA should be identified; they may extend from the nasal wings to the hypopharynx. Another important factor in this syndrome is the nervous influence on muscle tone of the hypopharynx, as well as the changes in blood pH, which are secondary to micro-arousals. Body position and sleep stage determine the severity. The pathophysiology of OSAHS should be understood to properly study a patient and provide the best treatment option.
ISSN:0120-0011
2357-3848
DOI:10.15446/revfacmed.v65n1Sup.60091