High-dose cytarabine-associated cerebellar toxicity: A case report

High-dose Arabinoside Cytarabine; Acute Myeloid Leukemia; Neurotoxicity INTRODUCTION Cytarabine is a pyrimidine analog which enters into the cells through a carrier process and then converted to its active compound, aracytidine triphosphate. [6] In some studies like Jolson et al., they highlighted c...

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Bibliographic Details
Published in:National journal of physiology, pharmacy and pharmacology pharmacy and pharmacology, 2018-01, Vol.7 (12), p.1-143
Main Authors: Varghese, Delcey, Joseph, Dawnwin, Prabhu, Raghuveer, N, Anila
Format: Article
Language:English
Subjects:
Abdomen
Ataxia
Case reports
Cell cycle
Chemotherapy
Deoxyribonucleic acid
DNA
Drug dosages
Leukemia
Neurotoxicity
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Summary:High-dose Arabinoside Cytarabine; Acute Myeloid Leukemia; Neurotoxicity INTRODUCTION Cytarabine is a pyrimidine analog which enters into the cells through a carrier process and then converted to its active compound, aracytidine triphosphate. [6] In some studies like Jolson et al., they highlighted certain risk factors for high-dose cytarabine-induced cerebellar toxicity, i.e., age >50 years, total dose >20 g/m2, type of leukemia, disease stage, severe hyperbilirubinemia (>3 mg/dl), abnormal pre-treatment liver function, and decreased creatinine clearance (
ISSN:2320-4672
2231-3206
DOI:10.5455/njppp.2018.8.0724818072017