Synthesis and cytotoxic activity of novel acyclic nucleoside analogues with functionality in click chemistry

We describe synthesis of novel acyclic nucleoside analogues which are building blocks for CuAAC reaction and their activity against two types of human cancer cell lines (HeLa, KB). Three of chosen compounds show promising cytotoxic activity. Synthesis pathway starting from simple and easily accessib...

Full description

Saved in:
Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2018-01, Vol.37 (1), p.53-66
Main Authors: Gładysz, Michał, Ruszkowski, Piotr, Milecki, Jan
Format: Article
Language:English
Subjects:
Adenosine
Anticancer nucleosides
Antiretroviral drugs
Cancer
Click chemistry
CuAAC
Cytotoxicity
DNA
Modified nucleosides
Nucleoside analogs
Thymidine
Tumor cell lines
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We describe synthesis of novel acyclic nucleoside analogues which are building blocks for CuAAC reaction and their activity against two types of human cancer cell lines (HeLa, KB). Three of chosen compounds show promising cytotoxic activity. Synthesis pathway starting from simple and easily accessible substrates employing DMT or TBDPS protective groups is described. Adenosine and thymidine analogues containing alkyne moiety and adenosine analogue containing azido group were synthesized. The obtained units showed ability of forming triazole motif under the CuAAC reaction conditions.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770.2017.1417598