IMMUNOHISTOCHEMICAL EXPRESSION OF ALPHA METHYLACYL-COA RACEMASE IN CARCINOMA PROSTATE IN PAKISTANI POPULATION

Material and Methods: All specimens of adenocarcinoma prostate diagnosed at Armed forces institute of pathology on the basis of immunohistochemistry and routine histopathology irrespective of age of patient, histological type or grade of the tumor were analyzed. After approval by Ethical Review Comm...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2017-12 (6), p.1054-1057
Main Authors: Tariq, Hassan, Ahmed, Rabia, Muhammad, Iqbal, Afzal, Saeed, Hashmi, Shoaib Naiyar, Hamdani, Syed Naeem Raza, Shahid, Arooj
Format: Article
Language:English
Subjects:
Age
Histopathology
Immunohistochemistry
Medical diagnosis
Pathology
Patients
Population
Prostate cancer
Studies
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Material and Methods: All specimens of adenocarcinoma prostate diagnosed at Armed forces institute of pathology on the basis of immunohistochemistry and routine histopathology irrespective of age of patient, histological type or grade of the tumor were analyzed. After approval by Ethical Review Committee, all specimens of adenocarcinoma prostate detected by routine histopathology and immunohistochemistry irrespective of age of patient, histological type and grade of the tumor, were included by non probability, consecutive sampling technique. Immunohistochemical stains for basal cells, such as HMWCK or more recently p63 are currently used in the diagnosis of focal prostate cancer but there are limitations in their use as negative staining for basal cell markers is by itself not diagnostic of carcinoma and also due to technical reasons these stains may be falsely positive thus it is necessary to interpret negative staining in an atypical focus in light of positive staining in adjacent benign glands which is used as an internal positive control. Alpha-methylacyl-CoA racemase: A variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy Am J Surg Pathol 2003; 27: 1128-33.
ISSN:0030-9648
2411-8842