PREVALENCE OF HUMAN LEUKOCYTE ANTIGEN B27 AMONG PATIENTS OF SPONDYLOARTHROPATHIES REFERRED TO A TERTIARY CARE CENTER

INTRODUCTION Spondyloarthropathies (SpA) are a group of related but phenotypically distinct disorders that encompass psoriatic arthritis, reactive arthritis, juvenile idiopathic arthritis, arthritis related to inflammatory bowel disease (IBD) and ankylosing spondylitis (AS)1. All the peripheral bloo...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2017-12 (6), p.958-961
Main Authors: Tipu, Hamid Nawaz, Bashir, Muhammad Mukarram
Format: Article
Language:English
Subjects:
Antigens
Arthritis
Flow cytometry
Haplotypes
HLA antigens
Immunoglobulins
Immunology
Males
Monoclonal antibodies
Pathogenesis
Population
Rheumatology
Software
Spondyloarthropathies
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Summary:INTRODUCTION Spondyloarthropathies (SpA) are a group of related but phenotypically distinct disorders that encompass psoriatic arthritis, reactive arthritis, juvenile idiopathic arthritis, arthritis related to inflammatory bowel disease (IBD) and ankylosing spondylitis (AS)1. All the peripheral blood samples of SpA patients sent to us for HLA-B27 testing by rheumatologists and orthopedic surgeons were included in the study, by non-probability consecutive sampling. RESULTS Over a course of 20 months of study period, we received a total of 329 peripheral blood samples for testing HLA-B27. In presence of clinical features, diagnostic probability of AS increases from 50% to 90% if HLA-B27 is positive. [...]its inclusion in presence of symptoms has been advocated since radiological findings are late to appear18.
ISSN:0030-9648
2411-8842