THERAPEUTIC EFFICACY OF COMBINATION THERAPY OF L-METHYLFOLATE AND ESCITALOPRAM IN DEPRESSION

According to the study the efficacy of L-Methylfolate and SSRI was 18.5% as compared to 7.04% efficacy of SSRI or SNRI monotherapy9. Criteria that excluded patients from the study included non consenting patients, presence of psychotic features in the current episode or a history of psychotic featur...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2017-12 (6), p.976-981
Main Authors: Kakar, Muhammad Siddique, Jehangir, Salim, Mustafa, Mansoor, Khattak, Haroon
Format: Article
Language:English
Subjects:
Antidepressants
Clinical trials
Comorbidity
Depression (Mood disorder)
Functional foods & nutraceuticals
Health aspects
Mental depression
Mental health
Patients
Psychiatry
Psychosis
Psychotropic drugs
Serotonin
Studies
Systematic review
Vitamin B
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Summary:According to the study the efficacy of L-Methylfolate and SSRI was 18.5% as compared to 7.04% efficacy of SSRI or SNRI monotherapy9. Criteria that excluded patients from the study included non consenting patients, presence of psychotic features in the current episode or a history of psychotic features; any bipolar disorder (current or past) or any psychotic disorder (current or past), any comorbidity including diabetes mellitus and hypertension, pregnancy, breastfeeding mothers, children and adolescents, patients with serious suicidal risk and patients taking Lithium, anticonvulsants, psychostimulants, antipsychotics or oral contraceptives. [...]it showed that combination of Escitalopram and L-Methylfolate was more effective than Escitalopram alone in treatment of moderate to severe depression. In another study it was seen that adding L-Methylfolate to selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) when starting pharmacotherapy leads to greater reduction of depressive symptoms in a shorter time compared with SSRI or SNRI monotherapy8.According to the study the efficacy of L-Methylfolate and SSRI was 18.5% as compared to 7.04% efficacy of SSRI or SNRI monotherapy9 showing a difference in response of 11.5% Papakostas et all showed that adjunctive L-methylfolate at 15mg/day showed significantly greater efficacy compared with continued SSRI therapy plus placebo on both primary outcome measures (response rate and degree of change in depression symptom score) and two secondary outcome measures of symptom severity10.
ISSN:0030-9648
2411-8842