Syndrome of Hypokalemic Metabolic Alkalosis and Hypomagnesemia Associated with Gentamicin Therapy: Case Reports

Nephrotoxicity, as evidenced by renal insufficiency is a well-known consequence of gentamicin therapy. We report two patients with gentamicin-induced syndrome of hypokalemic metabolic alkalosis and hypomagnesemia. Both had complete recovery of renal tubular function after cessation of antibiotic the...

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Bibliographic Details
Published in:Clinical pediatrics 2000-09, Vol.39 (9), p.529-533
Main Authors: Shetty, Avinash K., Rogers, N. Lynn, Mannick, Elizabeth E., Aviles, Diego H.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Adult
Alkalosis - chemically induced
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Biological and medical sciences
Cross Infection - drug therapy
Dose-Response Relationship, Drug
Drug therapy
Drug toxicity and drugs side effects treatment
Female
Gentamicins - administration & dosage
Gentamicins - adverse effects
Humans
Hypokalemia - chemically induced
Infant
Injections, Intravenous
Kidneys
Magnesium Deficiency - chemically induced
Male
Medical disorders
Medical sciences
Methicillin Resistance
Pediatrics
Pharmacology. Drug treatments
Syndrome
Toxicity: urogenital system
Treatment Outcome
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Summary:Nephrotoxicity, as evidenced by renal insufficiency is a well-known consequence of gentamicin therapy. We report two patients with gentamicin-induced syndrome of hypokalemic metabolic alkalosis and hypomagnesemia. Both had complete recovery of renal tubular function after cessation of antibiotic therapy. These cases emphasize the need to routinely monitor patients receiving gentamicin therapy for electrolyte abnormalities to avoid potential morbidity.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992280003900904