Use and safety of antiepileptic drugs in psychiatric inpatients—data from the AMSP study

The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993–2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoa...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2018-03, Vol.268 (2), p.191-208
Main Authors: Druschky, Katrin, Bleich, Stefan, Grohmann, Renate, Engel, Rolf R., Kleimann, Alexandra, Stübner, Susanne, Greil, Waldemar, Toto, Sermin
Format: Article
Language:English
Subjects:
Affective disorders
Antiepileptic agents
Carbamazepine
Convulsions & seizures
Drug screening
Edema
Hypersensitivity
Hyponatremia
Lamotrigine
Medicine
Medicine & Public Health
Neurosciences
Original Paper
Oxcarbazepine
Pharmacovigilance
Psychiatry
Psychosis
Schizoaffective disorder
Valproic acid
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Summary:The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993–2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoaffective disorder, and schizophrenic and organic psychoses. Valproic acid (VPA) was the most common substance across all of those groups, reaching administration rates of up to 50% since 2005, at which time carbamazepine (CBZ) administration consistently dropped below a rate of 10%. Lamotrigine (LTG) and pregabalin (PGB) increased in relevance after 2005 and 2010, respectively (with administration rates of up to 9%), whereas oxcarbazepine (OXC) was least prevalent (
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-017-0827-5