Folate targeted coated SPIONs as efficient tool for MRI

The development of more sensitive diagnostic tools allowing an early-stageand highly efficient medical imaging of tumors remains a challenge. Magneticnanoparticles seem to be the contrast agents with the highest potential, if properlyconstructed. Therefore, in this study, hybrid magnetic nanoarchite...

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Bibliographic Details
Published in:Nano research 2017-09, Vol.10 (9), p.3212-3227
Main Authors: Scialabba, Cinzia, Puleio, Roberto, Peddis, Davide, Varvaro, Gaspare, Calandra, Pietro, Cassata, Giovanni, Cicero, Luca, Licciardi, Mariano, Giammona, Gaetano
Format: Article
Language:English
Subjects:
Atomic/Molecular Structure and Spectra
Biocompatibility
Biomedicine
Biotechnology
Cancer
Chemistry and Materials Science
Condensed Matter Physics
Contrast agents
Diagnostic software
Diagnostic systems
Drug delivery systems
Folic acid
folic
acid
（FA）
Graft copolymers
Hyperthermia
Inulin
inulin
copolymer
Iron oxides
Magnetic properties
Magnetic resonance imaging
magnetic
resonance
imaging
（MRI）
Magnetite
Materials Science
Medical imaging
Nanoparticles
Nanotechnology
NMR
Nuclear magnetic resonance
Receptors
Research Article
superparamagnetic
spinel
iron
oxide
nanoparticles（SPIONs）
Tumors
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Summary:The development of more sensitive diagnostic tools allowing an early-stageand highly efficient medical imaging of tumors remains a challenge. Magneticnanoparticles seem to be the contrast agents with the highest potential, if properlyconstructed. Therefore, in this study, hybrid magnetic nanoarchitectures weredeveloped using a new amphiphilic inulin-based graft copolymer （INU-LA-PEG-FA） as coating material for 10-nm spinel iron oxide （magnetite, Fe304）superparamagnetic nanoparticles （SPION）. Folic acid （FA） covalently linked tothe coating copolymer in order to be exposed onto the nanoparticle surface waschosen as the targeting agent because folate receptors are upregulated in manycancer types. Physicochemical characterization and in vitro biocompatibilitystudy was then performed on the prepared magnetic nanoparticles. The improvedtargeting and imaging properties of the prepared FA-SPIONs were furtherevaluated in nude mice using 7-Tesla magnetic resonance imaging （MRI）.FA-SPIONs exhibited the ability to act as efficient contrast agents in conventionalMRI, providing a potential nanoplatform not only for tumor diagnosis but alsofor cancer treatment, through the delivery of anticancer drug or locoregional magnetic hvverthermia.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-017-1540-4