Pharmacological interaction of [alpha]-bisabolol and diclofenac on nociception, inflammation, and gastric integrity in rats

Preclinical Research & Development The combination of nonsteroidal anti-inflammatory drugs (NSAIDs) with herbal products having analgesic and anti-inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between [alpha]...

Full description

Saved in:
Bibliographic Details
Published in:Drug development research 2018-02, Vol.79 (1), p.29
Main Authors: Ortiz, Mario I, Carino-Cortes, Raquel, Ponce-Monter, Héctor A, Castaneda-Hernandez, Gilberto, Chavez-Pina, Aracely Evangelina
Format: Article
Language:English
Subjects:
Analgesics
Anti-inflammatory agents
Carrageenan
Damage
Diclofenac
Drug development
Drugs
Inflammation
Nonsteroidal anti-inflammatory drugs
Pain
Pain perception
Pharmacology
R&D
Rats
Research & development
Side effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preclinical Research & Development The combination of nonsteroidal anti-inflammatory drugs (NSAIDs) with herbal products having analgesic and anti-inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between [alpha]-bisabolol and the NSAID, diclofenac on nociception (formalin test), inflammation (paw inflammation produced by carrageenan) and gastric injury in rat was assessed. Diclofenac, [alpha]-bisabolol, or diclofenac-[alpha]-bisabolol combinations produced antinociceptive and anti-inflammatory effects in rat (p
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.21418