Copper‐Mediated Tandem C(sp2)‐H Amination and Annulation of Arenes with 2‐Aminopyridines: Synthesis of Pyrido‐fused Quinazolinone Derivatives

An efficient and convenient copper‐mediated tandem C(sp2)‐H amination and annulation of arenes with 2‐aminopyridines to provide 11H‐pyrido[2,1‐b]quinazolin‐11‐ones has been developed. A variety of benzamides and 2‐aminopyridines bearing different substituents are compatible with this transformation...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2018-02, Vol.360 (4), p.659-663
Main Authors: Liu, Jidan, Zou, Jinhui, Yao, Jiawei, Chen, Guoshu
Format: Article
Language:English
Subjects:
2-aminopyridine
Aromatic compounds
Chemical reactions
Copper
C−H activation
Organic chemistry
quinazolinone
tandem reaction
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Summary:An efficient and convenient copper‐mediated tandem C(sp2)‐H amination and annulation of arenes with 2‐aminopyridines to provide 11H‐pyrido[2,1‐b]quinazolin‐11‐ones has been developed. A variety of benzamides and 2‐aminopyridines bearing different substituents are compatible with this transformation
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201701286