Species‐specific role of gene‐adjacent retroelements in human and mouse gastric carcinogenesis

Helicobacter pylori (HP) infection promotes the recruitment of bone marrow stem cells into chronic gastritis lesions. Some of these marrow stem cells can differentiate into gastric epithelial cells and neoplastic cells. We propose that HP‐associated methylation could stabilize trans‐differentiation...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2018-04, Vol.142 (8), p.1520-1527
Main Authors: Rhyu, Mun‐Gan, Oh, Jung‐Hwan, Hong, Seung‐Jin
Format: Article
Language:English
Subjects:
aging
animal model
Bone marrow
Cancer
Carcinogenesis
Chronic infection
DNA methylation
Epigenetics
Epithelial cells
Gastric cancer
Gastritis
Health risks
Helicobacter pylori
Invasiveness
Lesions
Medical research
Metastases
Metastasis
Methylation
retroelements
Risk taking
Species diversity
Stem cell transplantation
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Helicobacter pylori (HP) infection promotes the recruitment of bone marrow stem cells into chronic gastritis lesions. Some of these marrow stem cells can differentiate into gastric epithelial cells and neoplastic cells. We propose that HP‐associated methylation could stabilize trans‐differentiation of marrow‐derived stem cells and that an unstable methylation status is associated with a risk of gastric cancer. Pathobiologic behavior of experimental mouse gastric cancer is mild compared to invasive and metastatic human gastric cancer. Differences in epigenetic stabilization of adult cell phenotypes between humans and mice could provide a foundation to explore the development of invasive and metastatic gastric cancer. Retroelements are highly repetitive sequences that play an essential role in the generation of species diversity. In this review, we analyzed retroelements adjacent to human and mouse housekeeping genes and proposed a possible epigenetic mechanism for HP‐associated carcinogenesis.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31120