Green tea seed oil reduces weight gain in C57BL/6J mice and influences adipocyte differentiation by suppressing peroxisome proliferator-activated receptor-[gamma]

Given that tea contains a number of chemical constituents possessing medicinal and pharmacological properties, green tea seed is also believed to contain many biologically active compounds such as saponin, flavonoids, vitamins, and oil materials. However, little is known about the physiologic functi...

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Published in:Pflügers Archiv 2008-11, Vol.457 (2), p.293
Main Authors: Kim, Na-hyung, Choi, Sun-kyung, Kim, Su-jin, Moon, Phil-dong, Lim, Hun-sun, Choi, In-young, Na, Ho-jeong, An, Hyo-jin, Myung, Noh-yil, Jeong, Hyun-ja, Um, Jae-young, Hong, Seung-heon, Kim, Hyung-min
Format: Article
Language:English
Subjects:
Cholesterol
Rodents
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Summary:Given that tea contains a number of chemical constituents possessing medicinal and pharmacological properties, green tea seed is also believed to contain many biologically active compounds such as saponin, flavonoids, vitamins, and oil materials. However, little is known about the physiologic functions of green tea seed oil. The aim of this study is to investigate the anti-obesity effects of green tea seed oil in C57BL/6J mice and in preadipocyte 3T3L-1 cell lines. In vivo, three groups of mice were fed with a standard diet, a high-fat diet containing 30% shortening, or 30% of green tea seed oil based on a standard diet for 85 days. The levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, glucose, and alanine aminotransferase in blood were analyzed at the end of the study. The mice given green tea seed oil gained less weight compared to mice given the shortening diet (p
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-008-0537-y