Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids

Although ovarian monodermal teratomas, including struma ovarii and carcinoids, are closely associated with mature teratomas, their genetic basis is poorly understood. A series of mature and monodermal ovarian teratomas were analyzed by short tandem repeat genotyping to evaluate their genetic zygosit...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2018-08, Vol.473 (2), p.177-182
Main Authors: Kato, Noriko, Sakamoto, Kazuhiro, Murakami, Koutaro, Iwasaki, Yuri, Kamataki, Akihisa, Kurose, Akira
Format: Article
Language:English
Subjects:
Adenoma
Deoxyribonucleic acid
DNA
Genotyping
Loci
Medicine
Medicine & Public Health
Meiosis
Neoplasia
Neoplasms
Original Article
Pathology
Patients
Teratoma
Tumors
Zygosity
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Summary:Although ovarian monodermal teratomas, including struma ovarii and carcinoids, are closely associated with mature teratomas, their genetic basis is poorly understood. A series of mature and monodermal ovarian teratomas were analyzed by short tandem repeat genotyping to evaluate their genetic zygosity and its associations. Informative DNA genotyping data were obtained for ten mature teratomas, six struma ovarii, and three carcinoids (one insular, one trabecular, and one mucinous). A homozygous genotype was present in five of the ten (50%) mature teratomas, three of the six (50%) struma ovarii, and one of the three (33%) ovarian carcinoids. There was no significant difference in genetic zygosity between mature and monodermal teratomas. Patients’ age was not correlated with the genetic zygosity: the youngest age in the homozygous tumor group of patients was 4 years. It is suggested that an oocyte after meiosis I, which has escaped from meiotic arrest, is a significant cause of these tumors. Although one mature teratoma was a rare case with lactating adenoma-like breast tissue, its genetic zygosity was concordant with that of the surrounding teratomatous tissue. In one ovarian carcinoid, the carcinoid and accompanying teratomatous components showed matching zygosity at all but one locus: the carcinoid was heterozygous but teratoma was homozygous at one pericentromeric locus. This suggests that not all carcinoids are secondary neoplasms arising from a fully developed mature teratoma: some are neoplasms deviating from a developing mature teratoma.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-018-2319-z