Cobalt‐Catalyzed Annulation Reactions via C−H Bond Activation

Considerable research attention has been directed towards the use of first‐row transition metals in organic synthesis. The more abundant, and less expensive cobalt is considered to be an effective alternative for expensive second and third‐row noble metals, especially in C−H bond functionalization r...

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Bibliographic Details
Published in:ChemCatChem 2018-02, Vol.10 (4), p.683-705
Main Authors: Prakash, Sekar, Kuppusamy, Ramajayam, Cheng, Chien‐Hong
Format: Article
Language:English
Subjects:
Activation
annulation
Chemical reactions
Cobalt
C−H activation
heterocycles
Hydrogen bonds
Noble metals
Organic chemistry
reductive elimination
Transition metals
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Summary:Considerable research attention has been directed towards the use of first‐row transition metals in organic synthesis. The more abundant, and less expensive cobalt is considered to be an effective alternative for expensive second and third‐row noble metals, especially in C−H bond functionalization reactions. In this Minireview, we will summarize the features, and recent achievements of the Co‐catalyzed directing group assisted C−H activation/cyclization reactions and their mechanistic insights. Cost‐effective cobalt: Highly cost‐effective and abundant, Co‐catalyzed C−H functionalization reactions have been developed that efficiently replaces the expensive noble metals in C−H bond activation reactions. This Minireview summarizes the recently emerged high‐valent CoIII‐catalyzed C−H activation/annulation strategies for the construction of heteroaromatic structures. Substantial mechanistic details and future challenges in this research field also have been discussed.
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201701559