Meal Frequency Differentially Alters Postprandial Triacylglycerol and Insulin Concentrations in Obese Women

The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high-carbohydrate meal frequency pattern in obese women. In a counterbalanced order, eight obese women completed two, 12-h conditions in which they co...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2013-01, Vol.21 (1), p.123-129
Main Authors: Heden, Timothy D., Liu, Ying, Sims, Lauren J., Whaley-Connell, Adam T., Chockalingam, Anand, Dellsperger, Kevin C., Kanaley, Jill A.
Format: Article
Language:English
Subjects:
Antioxidants
Biomarkers
Carbohydrates
Cardiovascular disease
Cholesterol
Diabetes
Fasting
Insulin
Lipids
Low density lipoprotein
Meals
Mens health
Metabolism
Obesity
Oxidative stress
Pathogenesis
Proteins
Studies
Womens health
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Summary:The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high-carbohydrate meal frequency pattern in obese women. In a counterbalanced order, eight obese women completed two, 12-h conditions in which they consumed 1,500 calories (14% protein, 21% fat, and 65% carbohydrate) either as three 500 calorie liquid meals every 4-h or six 250 calorie liquid meals every 2-h. Blood samples were taken every 30 min and analyzed for triacylglycerol (TAG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, myeloperoxidase, paraoxonase-1 activity, and insulin. The TAG incremental area under the curve (iAUC) during the three meal condition (321 ± 129 mg/dl.12 h) was significantly lower (P = 0.04) compared with the six meal condition (481 ± 155 mg/dl.12 h). The insulin iAUC during the three meal condition (5,549 ± 1,007 pmol/l.12 h) was significantly higher (P = 0.05) compared with the six meal condition (4,230 ± 757 pmol/l.12 h). Meal frequency had no influence on the other biochemical variables. Collectively, a three and six isocaloric high-carbohydrate meal frequency pattern differentially alters postprandial TAG and insulin concentrations but has no effect on postprandial cholesterol, oxidative stress, or antioxidant activity in obese women.
ISSN:1930-7381
1930-739X
DOI:10.1038/oby.2012.171