Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis

Atherosclerosis is the main cause of coronary artery disease -related deaths worldwide. The atheroprotective properties of pure tocotrienols (T3) in the absence of alpha-tocopherol (a-TCP) in vitamin E has not been extensively examined. To determine the atheroprotective properties of T3 in early and...

Full description

Saved in:
Bibliographic Details
Published in:Food & nutrition research 2016-01, Vol.60, p.1-9
Main Authors: Rahman, Thuhairah Abdul, Hassim, Noor Faezah, Zulkafli, Nurmazni, Muid, Suhaila, Kornain, Noor Kaslina, Nawawi, Hapizah
Format: Article
Language:English
Subjects:
Adhesion
Aorta
Arteriosclerosis
Atherosclerosis
Cardiovascular disease
Cell adhesion
Cell adhesion & migration
Cholesterol
Coronary artery
Coronary artery disease
Dietary supplements
E-selectin
Gelatinase B
Heart diseases
High cholesterol diet
Intercellular adhesion molecule 1
Interleukin 6
Lipids
Matrix metalloproteinase
Metalloproteinase
Rabbits
Tocopherol
Vascular cell adhesion molecule 1
Vitamin E
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atherosclerosis is the main cause of coronary artery disease -related deaths worldwide. The atheroprotective properties of pure tocotrienols (T3) in the absence of alpha-tocopherol (a-TCP) in vitamin E has not been extensively examined. To determine the atheroprotective properties of T3 in early and established atherosclerosis rabbits. Thirty New Zealand white rabbits were divided into two groups, B1 and B2 which represent early [fed 1% high cholesterol diet (HCD) for 2 weeks] and established (fed 1% HCD for 8 weeks) atherosclerosis. Each group was subdivided into three intervention arms: 1) T3-4 mg/kg, 2) T3-15 mg/kg and 3) vehicle without T3 (T3 negative) for 8 weeks. Serial fasting blood samples were obtained for lipid profile, and whole lengths of aorta were used to determine tissue markers of endothelial activation, inflammation and plaque stability. In B1, atherosclerotic lesion in T3-4 mg/kg group was significantly reduced (p =0.008), while aortic tissue expression of vascular cellular adhesion molecule 1 (VCAM-1), interleukin-6 (IL-6) and matrix metalloproteinase (MMP-12) was reduced in T3-4 mg/kg compared to T3-negative rabbits group (0.2±0.1 vs. 28.5±3.1%; 3.0±1.6 vs. 14.0±1.7%; and 5.2±2.2 vs. 27.7±0.8%, respectively,p
ISSN:1654-661X
DOI:10.3402/fnrv60.3l525