Phosphatases in Mouse Mast Cells Rapid IgE Desensitization: The Role of SHIP-1

Rationale Desensitization (DS) studies on murine IgE/mast cell (MC) model showed impairment of MC activation; receptor internalization, calcium mobilization, actin remodeling, degranulation, lipid mediators and cytokines production. Methods Sensitized murine bone marrow derived mast cells (mBMMCs) w...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB192-AB192
Main Authors: Alenazy, Leila A., de las Vecillas Sanchez, Leticia, Jimenez Rodriguez, Teodorikez W., Falck-Fuentes, Cintia A., Castells, Mariana C.
Format: Article
Language:English
Subjects:
Antigens
Desensitization
Desensitization (Psychology)
Mast cells
Ships
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Summary:Rationale Desensitization (DS) studies on murine IgE/mast cell (MC) model showed impairment of MC activation; receptor internalization, calcium mobilization, actin remodeling, degranulation, lipid mediators and cytokines production. Methods Sensitized murine bone marrow derived mast cells (mBMMCs) with anti-DNP IgE were either challenged or desensitized with 11 steps until target dose is reached (1ng DNP-HSA) as shown in (Sancho-Serra Mdel et al., 2011).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.610