Elevated levels of β6 integrin and alpha smooth actin positive microparticles in nasal lavage fluid in chronic rhinosinusitis with nasal polyps: a potential biomarker of epithelial-mesenchymal transition in the pathophysiology of polyp recurrence

JACI 2017). β6 integrin (ITGB6) is a specific epithelial cell surface protein up-regulated during repair and alpha smooth actin (αSMA) is an intracellular marker of EMT. Conclusions MPs positive for both αSMA and ITGB6 were significantly elevated in NLFs from CRSwNP, especially in subjects with asth...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB66-AB66
Main Authors: Takahashi, Toru, Kato, Atsushi, Berdnikovs, Sergejs, Stevens, Whitney W., Suh, Lydia A., Norton, James E., Carter, Roderick G., Harris, Kathleen E., Peters, Anju T., Hulse, Kathryn E., Grammer, Leslie C., Welch, Kevin C., Shintani-Smith, Stephanie, Tan, Bruce K., Conley, David B., Kern, Robert C., Schleimer, Robert P.
Format: Article
Language:English
Subjects:
Actin
Asthma
Mesenchyme
Microparticles
Polyps
Rhinitis
Rhinosinusitis
Sinusitis
Surgery
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Summary:JACI 2017). β6 integrin (ITGB6) is a specific epithelial cell surface protein up-regulated during repair and alpha smooth actin (αSMA) is an intracellular marker of EMT. Conclusions MPs positive for both αSMA and ITGB6 were significantly elevated in NLFs from CRSwNP, especially in subjects with asthma and recurrence of polyps, indicating that EMT is associated with the pathophysiology of nasal polyposis.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.210