Changes of DNA methylation and their association with changes in lung function during adolescence - an epigenome-wide study

Rationale Prior studies showed that DNA methylation (DNA-M) is associated with lung function and DNA-M at some cytosine-phosphate-guanine sites (CpGs) changes over time. Methods DNA-M was measured in peripheral blood samples collected at ages 10 (n = 329) and 18 years (n = 476) from the Isle of Wigh...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB202-AB202
Main Authors: Sunny, Shadia Khan, Zhang, Hongmei, Karmaus, Wilfried, Rezwan, Faisal I., White, Cory H., Relton, Caroline L., Henderson, A. John, Arshad, Syed H., Ewart, Susan, Holloway, John W.
Format: Article
Language:English
Subjects:
Adolescents
Child development
Deoxyribonucleic acid
DNA
DNA methylation
Lungs
Respiratory function
Teenagers
Online Access:Get full text
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Summary:Rationale Prior studies showed that DNA methylation (DNA-M) is associated with lung function and DNA-M at some cytosine-phosphate-guanine sites (CpGs) changes over time. Methods DNA-M was measured in peripheral blood samples collected at ages 10 (n = 329) and 18 years (n = 476) from the Isle of Wight birth cohort (UK) using Illumina Infinium HumanMethylation450 and EPIC Beadchips.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.639