Sustained silencing peanut allergy by xanthopurpurin is associated with suppression of peripheral and bone marrow IgE producing B cell

Serum peanut-specific IgE levels, hypersensitivity reactions following peanut challenge, splenocyte cytokine levels, and spleen and bone marrow IgE + B cells were assessed. The flow cytometry data revealed that XPP reduced peripheral and bone marrow IgE + B cells compared to the untreated group.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB201-AB201
Main Authors: Li, Xiu-Min, Srivastava, Kamal D., Chen, Yujuan, Yoo, Patrick, Liu, Changda, Uzun, Serife, Li, Hang, Nowak-Wegrzyn, Anna H., Yang, Nan
Format: Article
Language:English
Subjects:
Allergies
Anaphylaxis
Bone marrow
Food allergies
Immunoglobulin E
Lymphocytes B
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Description
Summary:Serum peanut-specific IgE levels, hypersensitivity reactions following peanut challenge, splenocyte cytokine levels, and spleen and bone marrow IgE + B cells were assessed. The flow cytometry data revealed that XPP reduced peripheral and bone marrow IgE + B cells compared to the untreated group.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.635