An Exaggerated Type I Interferon Antiviral Response is Associated with Exacerbations in Pediatric Asthma

Rationale Type-I interferon responses are critical to controlling viral upper respiratory tract infections (URIs), but excessive antiviral responses can have detrimental effects on the airway. Results URIs for which a virus was detected had significantly elevated expression of multiple interferon-as...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB116-AB116
Main Authors: Swanson, Cristina L., Babineau, Denise, Whalen, Elizabeth, Gill, Michelle A., Shao, Baomei, Liu, Andrew H., Jepson, Brett, Gruchalla, Rebecca S., O'Connor, George T., Pongracic, Jacqueline A., Kercsmar, Carolyn M., Khurana Hershey, Gurjit K., Zoratti, Edward M., Johnson, Christine Cole, Teach, Stephen J., Kattan, Meyer, Bacharier, Leonard B., Beigelman, Avraham, Sigelman, Steve M., Gergen, Peter J., Wheatley, Lisa M., Presnell, Scott, Togias, Alkis, Busse, William W., Jackson, Daniel J., Altman, Matthew C.
Format: Article
Language:English
Subjects:
Antiviral drugs
Asthma
Gene expression
Interferon
Pediatrics
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Summary:Rationale Type-I interferon responses are critical to controlling viral upper respiratory tract infections (URIs), but excessive antiviral responses can have detrimental effects on the airway. Results URIs for which a virus was detected had significantly elevated expression of multiple interferon-associated modules in both the upper airway and peripheral blood compared to baseline samples and compared to URIs without a detectable virus (fold changes 1.3-2.1, p
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.369