Chlamydia pneumoniae enhances CD4+ and CD8 +T effector memory cell IL-2 and IL-4 responses in stimulated peripheral blood mononuclear cells in human subjects

Previous studies in our laboratory identified significantly higher in vitro T lymphocyte responses to C. pneumoniae in children with asthma compared to healthy controls which may indicate the presence of T effector memory (TEM) lymphocytes. Methods Peripheral blood mononuclear cells (PBMC) (1x106/mL...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB123-AB123
Main Authors: Norowitz, Yitzchok M., Kohlhoff, Stephan, Banniettis, Natalie, Hammerschlag, Margaret R., Smith-Norowitz, Tamar A.
Format: Article
Language:English
Subjects:
CD4 antigen
CD8 antigen
Chlamydia
Chlamydia pneumoniae
Infections
Interleukin 2
Interleukin 4
Leukocytes (mononuclear)
Pathogens
Peripheral blood mononuclear cells
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Summary:Previous studies in our laboratory identified significantly higher in vitro T lymphocyte responses to C. pneumoniae in children with asthma compared to healthy controls which may indicate the presence of T effector memory (TEM) lymphocytes. Methods Peripheral blood mononuclear cells (PBMC) (1x106/mL) from adult healthy subjects were infected or mock-infected for 1h +/- C. pneumoniae TW-183 at a multiplicity of infection (MOI) =1.0, 0.1 or 0.01 and cultured for 24-48 hrs.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.390