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KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma - Impact on Airway Remodeling measured by MDCT
Post-hoc analysis of segmental airways in patients who had airflow obstruction at baseline (FEV1%
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| Published in: | Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB11-AB11 |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | AB11 |
| container_issue | 2 |
| container_start_page | AB11 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 141 |
| creator | Ilges, Daniel T. Zhou, L.I. Hall, Chase Sood, Shweta Kozlowski, James Goss, Charles Cahill, Katherine N. Cui, Jing Crosby-Thompson, Allison Jarjour, Nizar N. DiMango, Emily Erzurum, Serpil C. Trevor, Jennifer L. Wechsler, Michael E. Boyce, Joshua A. Israel, Elliot Castro, Mario |
| description | Post-hoc analysis of segmental airways in patients who had airflow obstruction at baseline (FEV1% |
| doi_str_mv | 10.1016/j.jaci.2017.12.035 |
| format | article |
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Conclusions These data suggest that inhibiting mast cells with imatinib may decrease the extent of airway remodeling in patients with severe asthma, especially in those with significant airflow obstruction.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2017.12.035</identifier><language>eng</language><publisher>St. Louis: Elsevier Inc</publisher><subject>Asthma ; Imatinib ; Inhibitor drugs ; Respiratory tract</subject><ispartof>Journal of allergy and clinical immunology, 2018-02, Vol.141 (2), p.AB11-AB11</ispartof><rights>2017</rights><rights>Copyright Elsevier Science Ltd. Feb 1, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1733-1a32d4b55d4a66b6d0e747d0e54818536e9ffa08ec6f2ef5402684684decfe5f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ilges, Daniel T.</creatorcontrib><creatorcontrib>Zhou, L.I.</creatorcontrib><creatorcontrib>Hall, Chase</creatorcontrib><creatorcontrib>Sood, Shweta</creatorcontrib><creatorcontrib>Kozlowski, James</creatorcontrib><creatorcontrib>Goss, Charles</creatorcontrib><creatorcontrib>Cahill, Katherine N.</creatorcontrib><creatorcontrib>Cui, Jing</creatorcontrib><creatorcontrib>Crosby-Thompson, Allison</creatorcontrib><creatorcontrib>Jarjour, Nizar N.</creatorcontrib><creatorcontrib>DiMango, Emily</creatorcontrib><creatorcontrib>Erzurum, Serpil C.</creatorcontrib><creatorcontrib>Trevor, Jennifer L.</creatorcontrib><creatorcontrib>Wechsler, Michael E.</creatorcontrib><creatorcontrib>Boyce, Joshua A.</creatorcontrib><creatorcontrib>Israel, Elliot</creatorcontrib><creatorcontrib>Castro, Mario</creatorcontrib><title>KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma - Impact on Airway Remodeling measured by MDCT</title><title>Journal of allergy and clinical immunology</title><description>Post-hoc analysis of segmental airways in patients who had airflow obstruction at baseline (FEV1% <80% predicted) treated with imatinib compared to placebo demonstrated an even greater improvement in WT% and WA% (-0.41 vs 0.09% P=<0.001; -0.89 vs 0.20%, P<0.001). Conclusions These data suggest that inhibiting mast cells with imatinib may decrease the extent of airway remodeling in patients with severe asthma, especially in those with significant airflow obstruction.</description><subject>Asthma</subject><subject>Imatinib</subject><subject>Inhibitor drugs</subject><subject>Respiratory tract</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMoOKd_wKuA1635aNIWvBnzazhRdF6HND1xKWs7k25j_96MeS0cck7C-74nPAhdU5JSQuVtkzbauJQRmqeUpYSLEzSipMwTWTBxikaElDSReVaeo4sQGhLvvChHKLzMFnjWLV3lBtd3uNrjWasH17kKuw6_xxG6IeCdG5b4E7bgAX-A9doMvd_jSRiWrcZJNK3jE44JE-d3eh9FbV_DynXfuAUdNh7qQ_jr_XRxic6sXgW4-utj9PX4sJg-J_O3p9l0Mk8MzTlPqOaszioh6kxLWcmaQJ7l8RRZQQvBJZTWalKAkZaBFRlhsshi1WAsCMvH6OaYu_b9zwbCoJp-47u4UjFCcsF4LnlUsaPK-D4ED1atvWu13ytK1AGuatQBrjrAVZSpCDea7o4miP_fOvAqmAjKQO08mEHVvfvP_gtz8II3</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Ilges, Daniel T.</creator><creator>Zhou, L.I.</creator><creator>Hall, Chase</creator><creator>Sood, Shweta</creator><creator>Kozlowski, James</creator><creator>Goss, Charles</creator><creator>Cahill, Katherine N.</creator><creator>Cui, Jing</creator><creator>Crosby-Thompson, Allison</creator><creator>Jarjour, Nizar N.</creator><creator>DiMango, Emily</creator><creator>Erzurum, Serpil C.</creator><creator>Trevor, Jennifer L.</creator><creator>Wechsler, Michael E.</creator><creator>Boyce, Joshua A.</creator><creator>Israel, Elliot</creator><creator>Castro, Mario</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>201802</creationdate><title>KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma - Impact on Airway Remodeling measured by MDCT</title><author>Ilges, Daniel T. ; Zhou, L.I. ; Hall, Chase ; Sood, Shweta ; Kozlowski, James ; Goss, Charles ; Cahill, Katherine N. ; Cui, Jing ; Crosby-Thompson, Allison ; Jarjour, Nizar N. ; DiMango, Emily ; Erzurum, Serpil C. ; Trevor, Jennifer L. ; Wechsler, Michael E. ; Boyce, Joshua A. ; Israel, Elliot ; Castro, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1733-1a32d4b55d4a66b6d0e747d0e54818536e9ffa08ec6f2ef5402684684decfe5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Asthma</topic><topic>Imatinib</topic><topic>Inhibitor drugs</topic><topic>Respiratory tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilges, Daniel T.</creatorcontrib><creatorcontrib>Zhou, L.I.</creatorcontrib><creatorcontrib>Hall, Chase</creatorcontrib><creatorcontrib>Sood, Shweta</creatorcontrib><creatorcontrib>Kozlowski, James</creatorcontrib><creatorcontrib>Goss, Charles</creatorcontrib><creatorcontrib>Cahill, Katherine N.</creatorcontrib><creatorcontrib>Cui, Jing</creatorcontrib><creatorcontrib>Crosby-Thompson, Allison</creatorcontrib><creatorcontrib>Jarjour, Nizar N.</creatorcontrib><creatorcontrib>DiMango, Emily</creatorcontrib><creatorcontrib>Erzurum, Serpil C.</creatorcontrib><creatorcontrib>Trevor, Jennifer L.</creatorcontrib><creatorcontrib>Wechsler, Michael E.</creatorcontrib><creatorcontrib>Boyce, Joshua A.</creatorcontrib><creatorcontrib>Israel, Elliot</creatorcontrib><creatorcontrib>Castro, Mario</creatorcontrib><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilges, Daniel T.</au><au>Zhou, L.I.</au><au>Hall, Chase</au><au>Sood, Shweta</au><au>Kozlowski, James</au><au>Goss, Charles</au><au>Cahill, Katherine N.</au><au>Cui, Jing</au><au>Crosby-Thompson, Allison</au><au>Jarjour, Nizar N.</au><au>DiMango, Emily</au><au>Erzurum, Serpil C.</au><au>Trevor, Jennifer L.</au><au>Wechsler, Michael E.</au><au>Boyce, Joshua A.</au><au>Israel, Elliot</au><au>Castro, Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma - Impact on Airway Remodeling measured by MDCT</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><date>2018-02</date><risdate>2018</risdate><volume>141</volume><issue>2</issue><spage>AB11</spage><epage>AB11</epage><pages>AB11-AB11</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>Post-hoc analysis of segmental airways in patients who had airflow obstruction at baseline (FEV1% <80% predicted) treated with imatinib compared to placebo demonstrated an even greater improvement in WT% and WA% (-0.41 vs 0.09% P=<0.001; -0.89 vs 0.20%, P<0.001). Conclusions These data suggest that inhibiting mast cells with imatinib may decrease the extent of airway remodeling in patients with severe asthma, especially in those with significant airflow obstruction.</abstract><cop>St. Louis</cop><pub>Elsevier Inc</pub><doi>10.1016/j.jaci.2017.12.035</doi></addata></record> |
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| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2018-02, Vol.141 (2), p.AB11-AB11 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | Elsevier |
| subjects | Asthma Imatinib Inhibitor drugs Respiratory tract |
| title | KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma - Impact on Airway Remodeling measured by MDCT |
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