CHANGES IN METABONOMIC PROFILE DURING PEANUT-INDUCED ANAPHYLAXIS AND CORRELATION WITH SYMPTOM

Methods We applied metabonomic profiling (NMR spectroscopy and mass spectrometry (MS)) to blood samples during peanut double-blind, placebo-controlled food challenges (DBPCFC). NMR profiling demonstrated statistically significant differences between reactive and placebo days for albumin hemoconcentr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-02, Vol.141 (2), p.AB85-AB85
Main Authors: Turner, Paul J., Garcia, Monica Ruiz, Skypala, Isabel J., Durham, Stephen R., Boyle, Robert J., Correia, Gonçalo D.S., Pearce, Jake T.M., Holmes, Elaine
Format: Article
Language:English
Subjects:
Anaphylaxis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Methods We applied metabonomic profiling (NMR spectroscopy and mass spectrometry (MS)) to blood samples during peanut double-blind, placebo-controlled food challenges (DBPCFC). NMR profiling demonstrated statistically significant differences between reactive and placebo days for albumin hemoconcentration (P=0.0011), concentration of triglyceride in VLDL lipoprotein (VLDL-6) particles (P=0.00031) and chemical shift in TSP (an internal control) which would be consistent with a fall in plasma pH (P=0.000033).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.274