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Association of the Factor V Leiden Mutation (1691G>A, Arg534Gln) with Ischemic Stroke in Nonvalvular Atrial Fibrillation in Turkish Population

In this disorder, the Leiden variant of factor V cannot be inactivated by activated protein C. The gene that codes the protein is referred to as facor V. Mutation of this gene a single nucleotide polymorphism (SNP) is located in exon 10. Atrial fibrillation (AF) is the commonest sustained cardiac ar...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2013-10, Vol.62 (18), p.C140-C140
Main Authors: İçli, Atilla, Erten, Nilgün, Türker, Yasin, Akçay, Salaheddin, Yücel, Habil, Yaşar, Erdoğan, Adalı, Mehmet Koray, Sütçü, Recep, Aksoy, Fatih
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Language:English
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Summary:In this disorder, the Leiden variant of factor V cannot be inactivated by activated protein C. The gene that codes the protein is referred to as facor V. Mutation of this gene a single nucleotide polymorphism (SNP) is located in exon 10. Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia, which confers a high risk of mortality and morbidity from stroke and thromboembolism We wanted to investigate Factor V Leiden Mutation (1691G>A, Arg534Gln) in patients with AF who have had a stroke than in healthy controls.Methods The factor V Leiden mutation was analysed in 70 patients with nonvalvuler AF who have had a stroke and 70 healthy individuals with no documented episode of AF matched for age, race and sex. GG), The number of patients carrying at least one A mutant allele (GA + AA) was significantly higher in AF patients who have had a stroke group than control (14 (20%) vs 5 (7.1%), p=0.026).Conclusıons In this study, our data suggest that the factor V Leiden mutation (1691G>A, Arg534Gln) may be associated with AF patients who have had a stroke from other clinical risk factors, but this should be confirmed in a much larger series of patients.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2013.08.419