Significance of cytoplasmic cyclin D1 expression in oral oncogenesis

Objectives To examine cytoplasmic cyclin D1 expression levels in oral carcinogenesis and evaluate their possible oncogenic significance and their clinicopathological and prognostic implications. Materials and Methods Immunohistochemical analysis of 69 oral squamous cell carcinomas (OSCCs) was perfor...

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Bibliographic Details
Published in:Oral diseases 2018-03, Vol.24 (1-2), p.98-102
Main Authors: Ramos‐García, P, Bravo, M, González‐Ruiz, L, González‐Moles, MÁ
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
cancer
Carcinogenesis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - secondary
CCND1
Cell migration
Cyclin D1
Cyclin D1 - metabolism
Cytology
Cytoplasm - metabolism
Female
Humans
Ki-67 Antigen - metabolism
Male
Middle Aged
Morphology
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
oral
oral carcinogenesis
Oral carcinoma
Oral squamous cell carcinoma
Squamous cell carcinoma
Tumorigenesis
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Summary:Objectives To examine cytoplasmic cyclin D1 expression levels in oral carcinogenesis and evaluate their possible oncogenic significance and their clinicopathological and prognostic implications. Materials and Methods Immunohistochemical analysis of 69 oral squamous cell carcinomas (OSCCs) was performed, revealing 23 with cytoplasmic cyclin D1 expression. We analyzed the association of the percentage of cyclin D1‐positive cells and the intensity of expression with TNM classification, tumor stage, differentiation degree, cell morphology, and Ki‐67 expression. Results Cytoplasmic cyclin D1 expression was associated with advanced tumor stage, poor differentiation, elevated Ki‐67 expression, and the presence of invasive cell morphology, indicators of a poor prognosis. An association was observed between nuclear and cytoplasmic expressions of cyclin D1. Conclusions Cytoplasmic expression of cyclin D1 appears to possess functions related to increased cell migration and invasion in OSCC.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12752