A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ?

• Published in: Osteoporosis international 2017-08, Vol.28 (8), p.2465-2473
• Main Authors: Hasegawa, T., Kawakita, A., Ueda, N., Funahara, R., Tachibana, A., Kobayashi, M., Kondou, E., Takeda, D., Kojima, Y., Sato, S., Yanamoto, S., Komatsubara, H., Umeda, M., Kirita, T., Kurita, H., Shibuya, Y., Komori, T.
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adult; Aged; Aged, 80 and over; Amputation; Antibiotics; Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology; Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control; Bisphosphonates; Bone Density Conservation Agents - administration & dosage; Bone Density Conservation Agents - adverse effects; Bone loss; Demography; Diphosphonates - administration & dosage; Diphosphonates - adverse effects; Drug Administration Schedule; Endocrinology; Humans; Jaw; Medicine; Medicine & Public Health; Middle Aged; Mobility; Mucosa; Multivariate analysis; Original Article; Orthopedics; Osteonecrosis; Retrospective Studies; Rheumatology; Risk Factors; Studies; Teeth; Tooth Extraction - adverse effects; Tooth Extraction - methods; Withholding Treatment; Wound Closure Techniques; Wound Healing; Wounds; Young Adult
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-017-4063-7

Summary Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an unclosed wound were significantly associated with increased risk of developing medication-related osteonecrosis of the jaw (MRONJ). We recommend a minimally traumatic extraction technique, removal of any bone edges, and mucosal wound closure as standard procedures in patients receiving bisphosphonates. Introduction Osteonecrosis of the jaws can occur following tooth extraction in patients receiving bisphosphonate drugs. Various strategies for minimizing the risk of MRONJ have been advanced, but no studies have comprehensively analyzed the efficacy of factors such as primary wound closure, demographics, and drug holidays in reducing its incidence. The purpose of this study was to retrospectively investigate the relationships between these various risk factors after tooth extraction in patients receiving oral bisphosphonate therapy. Methods Risk factors for MRONJ after tooth extraction were evaluated using univariate and multivariate analysis. All patients were investigated with regard to demographics; type and duration of oral bisphosphonate use; whether they underwent a discontinuation of oral bisphosphonates before tooth extraction (drug holiday), and the duration of such discontinuation; and whether any additional surgical procedures (e.g., incision, removal of bone edges, root amputation) were performed. Results We found that root amputation (OR = 6.64), extraction of a single tooth (OR = 3.70), bone loss or severe tooth mobility (OR = 3.60), and an unclosed wound (OR = 2.51) were significantly associated with increased risk of developing MRONJ. Conclusions We recommend a minimally traumatic extraction technique, removal of any bone edges, and mucosal wound closure as standard procedures in patients receiving bisphosphonates. We find no evidence supporting the efficacy of a pre-extraction short-term drug holiday from oral bisphosphonates in reducing the risk of MRONJ.