Sultams: Recent Syntheses and Applications

Sultams are very important scaffolds both in medicinal chemistry and in synthetic organic chemistry. Very important methodologies for the asymmetric and non‐asymmetric synthesis of sultams, including asymmetric synthesis with memory of chirality (MOC), have recently been developed. Nowadays sultams...

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Bibliographic Details
Published in:European journal of organic chemistry 2018-02, Vol.2018 (8), p.933-956
Main Authors: Debnath, Sudarshan, Mondal, Shovan
Format: Article
Language:English
Subjects:
Asymmetric synthesis
Asymmetry
Biological activity
Biological applications
Chemical synthesis
Chirality
Organic chemistry
Reaction mechanisms
Sultams
Synthesis
Synthetic applications
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Summary:Sultams are very important scaffolds both in medicinal chemistry and in synthetic organic chemistry. Very important methodologies for the asymmetric and non‐asymmetric synthesis of sultams, including asymmetric synthesis with memory of chirality (MOC), have recently been developed. Nowadays sultams are tremendously widely applied both in the medicinal field and in the synthetic field for the synthesis of different natural and non‐natural heterocycles. This review covers the recent development (2011–June 2017) of powerful methodologies for the synthesis of sultams and their applications in various fields during this period. A critical view of the mechanisms of the developed methodologies together with the scope and limitations of these methods add an extra dimension to the text. Recent powerful methodologies for the asymmetric and non‐asymmetric synthesis of sultams are reported. Synthetic and biological applications of sultams are also discussed.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201701491