Apoptosis: implications of basic research for clinical oncology

Recent studies have indicated a role for apoptosis in a variety of human diseases. Suppression of apoptosis contributes to carcinogenesis by several mechanisms, including facilitating the accumulation of gene mutations, permitting growth-factor-independent cell survival, promoting resistance to immu...

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Bibliographic Details
Published in:The lancet oncology 2001, Vol.2 (1), p.33-42
Main Authors: Tamm, Ingo, Schriever, Folke, Dörken, Bernd
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis Regulatory Proteins
Bcl-2-Like Protein 11
Cancer therapies
Carrier Proteins - physiology
Caspases - physiology
Cell cycle
Cell death
Cell division
Genes
Genetic engineering
Heat-Shock Proteins - physiology
Humans
Leukemia
Lymphoma
Medical Oncology
Membrane Proteins
Mutation
Neoplasms - drug therapy
Neoplasms - genetics
Proteins
Proto-Oncogene Proteins
Signal transduction
Transgenic animals
Tumors
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Summary:Recent studies have indicated a role for apoptosis in a variety of human diseases. Suppression of apoptosis contributes to carcinogenesis by several mechanisms, including facilitating the accumulation of gene mutations, permitting growth-factor-independent cell survival, promoting resistance to immune-based cytotoxicity, and allowing bypassing of cell-cycle checkpoints, which would normally induce apoptosis. Defects in apoptotic mechanisms also play an important part in resistance to chemotherapy and radiation. The core machinery of the cell death pathway can be reduced to a few critical types of proteins, which are well conserved across animal evolution. This review gives an update on the key players involved in apoptosis as well as an overview of the involvement of apoptosis in disease, and novel diagnostic and therapeutic options derived from the extensive basic research on this topic carried out over the last decade.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(00)00193-5