The hypothalamic-pituitary-testicular axis and the testicular function are modulated after silver nanoparticle exposure

Silver nanoparticles (AgNPs) are widely used in industrial and medical applications and humans may be exposed through different routes, increasing the risk of toxicity. We investigated the transcript expression of genes involved in the regulation of the hypothalamic-pituitary-testicular (HPT) axis a...

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Bibliographic Details
Published in:Toxicology research (Cambridge) 2018-01, Vol.7 (1), p.102-116
Main Authors: Cavallin, M D, Wilk, R, Oliveira, I M, Cardoso, N C S, Khalil, N M, Oliveira, C A, Romano, M A, Romano, R M
Format: Article
Language:English
Subjects:
Chemical activity
Endocrine disruptors
Exposure
Gene expression
Gene regulation
Genes
Hypothalamic-pituitary-thyroid axis
Hypothalamus
Nanoparticles
Parameters
Pituitary
Puberty
Silver
Sperm
Spermatogenesis
Testes
Toxicity
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Summary:Silver nanoparticles (AgNPs) are widely used in industrial and medical applications and humans may be exposed through different routes, increasing the risk of toxicity. We investigated the transcript expression of genes involved in the regulation of the hypothalamic-pituitary-testicular (HPT) axis and the parameters associated with sperm functionality after prepubertal exposure. AgNPs modulated the transcript expression of genes involved in the control of the HPT axis and spermatogenesis in the groups treated with lower doses, while the functional parameters related to sperm and puberty were affected in the groups administered higher doses. These results suggest that the HPT axis is disrupted by AgNPs during the prepubertal and pubertal periods, which are highly susceptible windows for the endocrine-disrupting chemical activity.
ISSN:2045-452X
2045-4538
DOI:10.1039/c7tx00236j