High throughput mechanochemistry: application to parallel synthesis of benzoxazines

We describe herein an unprecedented mechanochemical " parallel synthesis " of 3,4-dihydro-2 H -benzo[ e ][1,3]oxazine derivatives via a one pot three component reaction. The new milling system uses a multiposition jar (variable sizes are possible), allowing for the processing of up to 12 s...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-01, Vol.54 (5), p.551-554
Main Authors: Martina, K, Rotolo, L, Porcheddu, A, Delogu, F, Bysouth, S. R, Cravotto, G, Colacino, E
Format: Article
Language:English
Subjects:
Benzoxazines
Fungicides
Synthesis
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Summary:We describe herein an unprecedented mechanochemical " parallel synthesis " of 3,4-dihydro-2 H -benzo[ e ][1,3]oxazine derivatives via a one pot three component reaction. The new milling system uses a multiposition jar (variable sizes are possible), allowing for the processing of up to 12 samples simultaneously, leading to the formation of a fungicide and a building block for polymer preparation with higher throughput compared to standard milling devices. Mechanochemical "parallel synthesis": processing 12 samples simultaneously allowed fast screening of the optimum reaction conditions and high throughput preparation of benzozaxine derivatives, including a fungicide.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07758k