Marine natural products

• Published in: Natural product reports 2018-01, Vol.35 (1), p.8-53
• Main Authors: Blunt, John W, Carroll, Anthony R, Copp, Brent R, Davis, Rohan A, Keyzers, Robert A, Prinsep, Michèle R
• Format: Article
• Language: English
• Subjects: Algae; Animals; Aquatic Organisms - chemistry; Aquatic Organisms - metabolism; Biological Products - chemistry; Biological Products - pharmacology; Bryozoa - chemistry; Chlorophyta - chemistry; Cnidaria - chemistry; Echinodermata - chemistry; Literature reviews; Mangroves; Marine microorganisms; Microorganisms; Molecular Structure; Mollusca - chemistry; Mollusks; Natural products; Phaeophyceae - chemistry; Phytoplankton; Phytoplankton - chemistry; Porifera - chemistry; Rhodophyta - chemistry; Seawater - microbiology; Shellfish; Urochordata - chemistry; Wetlands
• ISSN: 0265-0568; 1460-4752
• DOI: 10.1039/c7np00052a

Covering: 2016. Previous review: Nat. Prod. Rep. , 2017, 34 , 235-294 This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. This review of 2016 literature describes the structures and biological activities of 1277 new marine natural products and the structure revision and absolute configuration of previously reported MNPs. The chemical diversity of 28 609 MNPs reported since 1957 is also investigated and compared to that of approved drugs.