A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

A green, one-pot approach based on the solvothermal amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. It does not require the use of catalysts or coupling reagents and it occurs in the presence of ethanol that has been proved to...

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Published in:Green chemistry : an international journal and green chemistry resource : GC 2018, Vol.20 (2), p.375-381
Main Authors: Dalu, Francesca, Scorciapino, Mariano A., Cara, Claudio, Luridiana, Alberto, Musinu, Anna, Casu, Mariano, Secci, Francesco, Cannas, Carla
Format: Article
Language:English
Subjects:
Aliphatic compounds
Amides
Amines
Biological activity
Carboxylic acids
Catalysis
Catalysts
Chemical synthesis
Ethanol
Green chemistry
Reagents
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cited_by cdi_FETCH-LOGICAL-c296t-70faea5a587a4e2404743886ccab91e7deec8212ffc701e13d02d0aa5564df5c3
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container_title Green chemistry : an international journal and green chemistry resource : GC
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creator Dalu, Francesca
Scorciapino, Mariano A.
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description A green, one-pot approach based on the solvothermal amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. It does not require the use of catalysts or coupling reagents and it occurs in the presence of ethanol that has been proved to have a key role in the process. The proposed strategy is also extendable to biologically active amides and could represent a low-cost and waste-less alternative to the common synthetic pathways.
doi_str_mv 10.1039/C7GC02967E
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issn 1463-9262
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source Royal Society of Chemistry
subjects Aliphatic compounds
Amides
Amines
Biological activity
Carboxylic acids
Catalysis
Catalysts
Chemical synthesis
Ethanol
Green chemistry
Reagents
title A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides
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